The number 16 keeps popping up.
When Jack found the pilot he told them it had been 16 hours since they had crashed.
When Locke was showing Walt the backgammon game the dice added up to 16.
The message from the french woman has been replaying for 16 years
In Sun's flashback, Jack was at the counter and said he had to be back to LA in 16 hours.

I'm sure there are others, but I haven't been able to see all the episodes yet.

Is this something important we should take note of?

No.

BWAHAHAHAHA!

Thanks David, heard it someplace else and it had me thinking....